THE SMART TRICK OF PKRRATING THAT NOBODY IS DISCUSSING

The activated enzyme then phosphorylates its important substrate, the translational initiation component eIF2α. The resulting translational arrest blocks viral replication. PKR belongs into a conserved family members of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to distinctive stimuli12, triggering the